An architecture for autonomic web service process planning

Web service composition is a technology that has received considerable attention in the last number of years. Languages and tools to aid in the process of creating composite web services have been received specific attention. Web service composition is the process of linking single web services together in order to accomplish more complex tasks. One area of web service composition that has not received as much attention is the area of dynamic error handling and re-planning, enabling autonomic composition. Given a repository of service descriptions and a task to complete, it is possible for AI planners to automatically create a plan that will achieve this goal. If however a service in the plan is unavailable or erroneous the plan will fail. Motivated by this problem, this paper suggests autonomous re-planning as a means to overcome dynamic problems. Our solution involves automatically recovering from faults and creating a context-dependent alternate plan

Subscale Assessment of the NEI-RQL-42 Questionnaire with Rasch Analysis

This article is made available with the permission of the publisher, Association for Research in Vision and OphthalmologyPurpose.: To explore the psychometric properties of the 13 subscales of the NEI-RQL-42 questionnaire using Rasch analysis. Methods.: The NEI-RQL-42 is a refractive error-related quality of life (QoL) questionnaire with a complex design; its 13 subscales contain 42 questions, which include 16 different question/response category formats. It was completed by 100 laser refractive surgery subjects (spectacle and contact lens wearers) pre- and postoperatively. Rasch analysis was used to assess the use of response categories, success in measuring a single trait per subscale (unidimensionality), ability to discriminate persons (precision), and targeting of the questions to person QoL. Results.: Response categories were misused in four subscales (clarity of vision, diurnal fluctuation, symptoms, and appearance), which required repair before further analyses. Six subscales contained items that did not contribute to a single trait measurement (multidimensional). All subscales were found to be inadequate at distinguishing between persons (person separation >2.0), and targeting of the questions to QoL was poor for six subscales. Conclusions.: The NEI-RQL-42 questionnaire is deficient for all psychometric properties tested. Clinicians or researchers wishing to measure QoL related to refractive error correction should consider other questionnaires that have been rigorously developed and meet standard psychometric properties

Group Assessments to Help Build Online Learning Communities in Biomedical Science Distance Learning Programmes

Introduction: Biomedical Science distance learning courses offer flexibility in study while in employment. Asynchronous and self-learning approaches are common within such courses and often student-student interaction is limited. The aims of this study were to establish learning communities, develop confidence in participating in online teamwork and foster an appreciation of transferable skills including digital capabilities through remote group activities. Materials and Methods: Two cohorts of students (n = 20/n = 21) were enrolled in a microbiology module of an IBMS accredited MSc distance learning course. Groups of 4–5 students produced a digital output relating to current global infection-related issues, namely, assignment 1, production of a slide deck, which peers could use as learning resources and assignment 2, a voiceover PowerPoint debate, and infographic, voting assessment and peer/self-marking. Students also prepared reflections using written format and a FlipGrid video-recording. A qualitative content analysis was conducted on reflections from all students. Students completed a pre- and post-assignment survey focused on the development of transferable skills for the biomedical sector. Results: Students’ skills and confidence increased following completion of the group assignment, as evident from the pre- and post-questionnaire responses, namely, possession of digital skills and digital creation abilities (29% v 83%), applying for jobs which require digital skills (54% v 89%), talking about examples of using digital media during job interviews (21% v 78%) and demonstration of creativity during assignment tasks (33% v 90%). Critical thinking was more commonly demonstrated during the debate in comparison to the slide deck activity (p = 0.001). The importance of developing digital skills, was higher following completion of the group activities (p = 0.03). Students reflected on the value of the group activities in relation to knowledge acquisition (85%, 86%), collegiality (70%, 71%), digital skills development (80%, 90%), the fact that the activities were enjoyable (70%, 67%) and the development of peer interaction and support (50%, 67%) in relation to assignment 1 and 2, respectively. Discussion: Increasingly digital technologies are being used in the healthcare sector resulting in updated HCPC Standards of Proficiency. This study highlights that virtual group activities promote the establishment of supportive learning communities and the development of transferable skills including digital capabilities for application within the biomedical science workplace

The development of an instrument to measure quality of vision: the quality of vision (QoV)

PURPOSE. To develop an instrument to measure subjective quality of vision: the Quality of Vision (QoV) questionnaire. METHODS. A 30-item instrument was designed with 10 symptoms rated in each of three scales (frequency, severity, and bothersome). The QoV was completed by 900 subjects in groups of spectacle wearers, contact lens wearers, and those having had laser refractive surgery, intraocular refractive surgery, or eye disease and investigated with Rasch analysis and traditional statistics. Validity and reliability were assessed by Rasch fit statistics, principal components analysis (PCA), person separation, differential item functioning (DIF), item targeting, construct validity (correlation with visual acuity, contrast sensitivity, total root mean square [RMS] higher order aberrations [HOA]), and test-retest reliability (two-way random intraclass correlation coefficients [ICC] and 95% repeatability coefficients [R c ]). RESULTS. Rasch analysis demonstrated good precision, reliability, and internal consistency for all three scales (mean square infit and outfit within 0.81-1.27; PCA Ͼ60% variance explained by the principal component; person separation 2.08, 2.10, and 2.01 respectively; and minimal DIF). Construct validity was indicated by strong correlations with visual acuity, contrast sensitivity and RMS HOA. Test-retest reliability was evidenced by a minimum ICC of 0.867 and a minimum 95% R c of 1.55 units. CONCLUSIONS. The QoV Questionnaire consists of a Raschtested, linear-scaled, 30-item instrument on three scales providing a QoV score in terms of symptom frequency, severity, and bothersome. It is suitable for measuring QoV in patients with all types of refractive correction, eye surgery, and eye disease that cause QoV problems. (Invest Ophthalmol Vis Sci. 2010;51:5537-5545) DOI:10.1167/iovs.10-5341 Q uality of vision (QoV) is a subjective entity based on an individual's unique perception of his or her vision. This perception is multifactorial, consisting not only of visual factors but also of psychological factors. Although optics and vision can be easily measured, none of these measurements explain how the patient subjectively perceives his or her vision; they provide only an indication. 1 Two patients may have identical visual function in terms of objective and subjective testing but very different perception of their QoV. Eye disease, refractive surgery, spectacles, and contact lenses may change QoV. 2-9 Therefore, the patient's perception of QoV may be an important outcome measure, but measuring perception requires a thoroughly developed and validated questionnaire. Many vision-related questionnaires have been developed, but none that specifically measures only QoV. Some instruments include QoV questions, but the questions are mixed in with the measurement of other latent traits such as visual disability. 10 -14 This combining of traits is a problem because all items that are combined to produce a score should measure a single trait; otherwise, the meaning of the measurement is unclear. 15 Second, averaging scores across all items erroneously assumes that the result provides an interval scale. It cannot be assumed that the difficulty of all questions is the same and the difficulty step between each category is constant; hence, the scaling may not be additive or linearly related to the trait under investigation. 16 Such instruments are inadequate for dealing with unanswered items and are not suitable to arithmetic functions. Item response models such as Rasch analysis have demonstrated the limitations in traditional summary (Likert) scoring 21 Rasch analysis consists of a family of psychometric models that provides a valid measurement of the latent trait, in this case, QoV, with recognized superiority over summary scoring methods. METHODS Prestudy and Questionnaire Design Items were identified via an extensive literature review and in focus groups with nonexperts and experts in the fields of refractive correction, questionnaire design, and subject interviews, to ensure content validity. The items were constructed and written at a comprehension level suitable for a 12-year-old

VKORC1 sequence variants associated with resistance to anticoagulant rodenticides in Irish populations of Rattus norvegicus and Mus musculus domesticus

While resistance to anticoagulant rodenticides is known to occur in many European populations of Norway rat and house mouse, to-date no data is available on the occurrence in Ireland of such resistance. No genetic evidence for the occurrence of resistance was found in 65 Norway rat samples analysed, indicative of an absence, or low prevalence, of resistance in rats in at least the Eastern region of the island of Ireland. The presence of two of the most commonly found amino acid substitutions Leu128Ser and Tyr139Cys associated with house mouse resistance to anticoagulant rodenticides was confirmed. The occurrence of two such mutations is indicative of the occurrence of resistance to anticoagulant rodenticides in house mice in the Eastern region of the island of Ireland

Proteomics Analysis and Protein Expression during Sporozoite Excystation of Cryptosporidium parvum (Coccidia, Apicomplexa)

Cryptosporidiosis, caused by coccidian parasites of the genus Cryptosporidium, is a major cause of human gastrointestinal infections and poses a significant health risk especially to immunocompromised patients. Despite intensive efforts for more than 20 years, there is currently no effective drug treatment against these protozoa. This study examined the zoonotic species Cryptosporidium parvum at two important stages of its life cycle: the non-excysted (transmissive) and excysted (infective) forms. To increase our understanding of the molecular basis of sporozoite excystation, LC-MS/MS coupling with a stable isotope N-terminal labeling strategy using iTRAQ (TM) reagents was used on soluble fractions of both non-excysted and excysted sporozoites, i.e. sporozoites both inside and outside oocysts were examined. Sporozoites are the infective stage that penetrates small intestinal enterocytes. Also to increase our knowledge of the C. parvum proteome, shotgun sequencing was performed on insoluble fractions from both non-excysted and excysted sporozoites. In total 303 C. parvum proteins were identified, 56 of which, hitherto described as being only hypothetical proteins, are expressed in both excysted and non-excysted sporozoites. Importantly we demonstrated that the expression of 26 proteins increases significantly during excystation. These excystation-induced proteins included ribosomal proteins, metabolic enzymes, and heat shock proteins. Interestingly three Apicomplexa-specific proteins and five Cryptosporidium-specific proteins augmented in excysted invasive sporozoites. These eight proteins represent promising targets for developing vaccines or chemotherapies that could block parasite entry into host cells

Defining métier for the Celtic Sea mixed fisheries: A multiannual international study of typology

There is growing international focus on ecosystem based fisheries management. Within the EU this has manifested in the provision of mixed fisheries advice, using the FCube model. The operational implementation and accuracy of this model relies on accurate identification of the technical interactions between fleets, gears and the resulting composition of species in the retained catch. These interactions are defined using units of fishing activity based on gear type and target species assemblage, but with no consideration for spatiotemporal heterogeneity. We assess the relevance of the fishing units used in relation to the spatial and temporal trends in retained catch within the Celtic Sea. To achieve this multivariate analysis (principal component and hierarchical clustering) were conducted to identify homogenous groupings of fishing activity using 5 years of international Celtic Sea retained catch data. The groupings identified demonstrate that a fairly simplistic structure of fishing activity units (country of provenance, fishing location, gear and target species) can effectively describe the complex mixed fisheries scenarios being executed within the Celtic Sea consistently across multiple years. This international and multiannual analysis improves our understanding of the mixed fisheries scenarios within the Celtic Sea and reveals a multifaceted spatial structure in the species assemblages landed, indicating the presence of several distinct mixed fisheries within the region appropriate for mixed fisheries analyses

Atmospheric carbon dioxide variability in the Community Earth System Model : evaluation and transient dynamics during the twentieth and twenty-first centuries

Author Posting. © American Meteorological Society, 2013. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Journal of Climate 26 (2013): 4447–4475, doi:10.1175/JCLI-D-12-00589.1.Changes in atmospheric CO2 variability during the twenty-first century may provide insight about ecosystem responses to climate change and have implications for the design of carbon monitoring programs. This paper describes changes in the three-dimensional structure of atmospheric CO2 for several representative concentration pathways (RCPs 4.5 and 8.5) using the Community Earth System Model–Biogeochemistry (CESM1-BGC). CO2 simulated for the historical period was first compared to surface, aircraft, and column observations. In a second step, the evolution of spatial and temporal gradients during the twenty-first century was examined. The mean annual cycle in atmospheric CO2 was underestimated for the historical period throughout the Northern Hemisphere, suggesting that the growing season net flux in the Community Land Model (the land component of CESM) was too weak. Consistent with weak summer drawdown in Northern Hemisphere high latitudes, simulated CO2 showed correspondingly weak north–south and vertical gradients during the summer. In the simulations of the twenty-first century, CESM predicted increases in the mean annual cycle of atmospheric CO2 and larger horizontal gradients. Not only did the mean north–south gradient increase due to fossil fuel emissions, but east–west contrasts in CO2 also strengthened because of changing patterns in fossil fuel emissions and terrestrial carbon exchange. In the RCP8.5 simulation, where CO2 increased to 1150 ppm by 2100, the CESM predicted increases in interannual variability in the Northern Hemisphere midlatitudes of up to 60% relative to present variability for time series filtered with a 2–10-yr bandpass. Such an increase in variability may impact detection of changing surface fluxes from atmospheric observations.The CESM project is supported by the National Science Foundation and the Office of Science (BER) of the U.S. Department of Energy. Computing resources were provided by the Climate Simulation Laboratory at NCAR’s Computational and Information Systems Laboratory (CISL), sponsored by the National Science Foundation and other agencies. G.K.A. acknowledges support of a NOAA Climate and Global Change postdoctoral fellowship. J.T.R., N.M.M., S.C.D., K.L., and J.K.M. acknowledge support of Collaborative Research: Improved Regional and Decadal Predictions of the Carbon Cycle (NSF AGS-1048827, AGS-1021776,AGS-1048890). TheHIPPO Programwas supported byNSF GrantsATM-0628575,ATM-0628519, and ATM-0628388 to Harvard University, University of California (San Diego), and by University Corporation for Atmospheric Research, University of Colorado/ CIRES, by the NCAR and by the NOAAEarth System Research Laboratory. Sunyoung Park, Greg Santoni, Eric Kort, and Jasna Pittman collected data during HIPPO. The ACME project was supported by the Office of Biological and Environmental Research of the U.S. Department of Energy under Contract DE-AC02- 05CH11231 as part of the Atmospheric Radiation Measurement Program (ARM), the ARM Aerial Facility, and the Terrestrial EcosystemScience Program. TCCON measurements at Eureka were made by the Canadian Network for Detection of Atmospheric Composition Change (CANDAC) with additional support from the Canadian Space Agency. The Lauder TCCON program was funded by the New Zealand Foundation for Research Science and Technology contracts CO1X0204, CO1X0703, and CO1X0406. Measurements at Darwin andWollongong were supported by Australian Research Council Grants DP0879468 and DP110103118 and were undertaken by David Griffith, Nicholas Deutscher, and Ronald Macatangay. We thank Pauli Heikkinen, Petteri Ahonen, and Esko Kyr€o of the Finnish Meteorological Institute for contributing the Sodankyl€a TCCON data. Measurements at Park Falls, Lamont, and Pasadena were supported byNASAGrant NNX11AG01G and the NASA Orbiting Carbon Observatory Program. Data at these sites were obtained by Geoff Toon, Jean- Francois Blavier, Coleen Roehl, and Debra Wunch.2014-01-0